Research Interests

Protein degradation by the Ubiquitin-Proteasome System (UPS) is essential to maintain cellular homeostasis and dysregulation in components of the UPS leads to age-related diseases. E3 ubiquitin ligases are key components of the UPS, transferring ubiquitin from a loaded E2-conjugating enzyme and onto lysines of a protein substrate. Therefore, understanding how these enzymes function at the molecular level is important for our fundamental understanding of protein degradation and also because E3s have a strong potential as novel drug targets.

 

1. Define the biochemical and structural properties of HECT E3 ubiquitin ligases.

Lee Harris, ARUK-funded PhD student

Collaboration with Dr John Burke, University of Victoria, Canada; Professor Benedikt Kessler, University of Oxford; Dr Eric Strieiter; Dr Farid El-Oualid, UbiQ; Dr Satpal Virdee, MRC-PPU university of Dundee

2. Determine the role and function of HECT E3 ubiquitin ligases in the Brain.

Sarah Jasem (Kuwait Science Scholarship, 2015-2019)

Collaboration with Dr Rob Williams, University of Bath; Professor Paul Verkade, Wolfson Imaging Center University of Bristol.

3. Determine how mutant ubiquitin (UBB+1) is regulated in Alzheimer’s Disease.

Lee Harris, ARUK-funded PhD student (2017-2021);

Collaboration with Dr Rob Williams, University of Bath; Professor Pat Kehoe and Professor Seth Love, South West Dementia Brain Bank.

2. Determine the function of novel ubiquitin-dependent molecular mechanisms in the cell cycle, and their relevance for brain cancer.

Natalie Vaughan Bath-University Research Studentship (2014-2018); Niko Scholtz GW4 MRC BioMed studentship (2018-2022).

Collaboration with Dr Catherine Lindon, University of Cambridge; Dr Kathreena Kurian, Brain Tumour Research Group, Institute of Clinical Neuroscience, University of Bristol; Dr Florian Siebzehnrubl, ECSCI Cardiff University; Dr Mariann Bienz MRC-LMB Cambridge; Professor Benedikt Kessler, University of Oxford.

 

 

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